Week 8 NFL Odds, Lines, Spreads, Betting Predictions: Picks, Best Bets Today from Proven Model

NFL Week 8 presents a slate of intriguing matchups for bettors, filled with familiar faces facing off against their former teams. While there are no international games or double-header Monday Night Football contests this week, the schedule is rich with compelling storylines and potential upsets.

One of the most anticipated games is the Sunday night showdown between Aaron Rodgers and the Green Bay Packers. The Packers are currently favored by 3 points on the road, according to the latest NFL odds. This game marks Rodgers’ first encounter against his former team, adding an extra layer of intrigue to the contest.

However, Rodgers isn’t the only player seeking revenge or proving a point this week. Saquon Barkley will face his former team, the New York Giants, as the Eagles are favored by 7 points. Joe Flacco will reunite with the other New York team when the Bengals take on the Jets (+6). Javonte Williams, currently the league’s second-leading rusher, will face his former team, the Denver Broncos, as the Cowboys are underdogs by 3.5 points. Smart NFL betting strategies will take into account the "revenge factor" and the motivation of players facing teams that moved on without them.

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To help navigate these Week 8 matchups, SportsLine’s advanced computer model has simulated each game 10,000 times, providing valuable insights and predictions for every contest. This model has a proven track record, boasting a profit of over $7,000 for $100 players on top-rated NFL picks since its inception. It is currently on a sizzling 43-28 run on top-rated picks dating back to 2024.

The model has identified several key games to watch in Week 8. One of its strongest picks is that the Cleveland Browns (+7, 40.5) will cover the spread against the New England Patriots in their Sunday 1 p.m. ET kickoff. Cleveland is coming off a dominant 25-point victory over Miami, marking their third-largest win margin in the past 30 years. The Browns boast the league’s top-ranked total defense, limiting opponents to a league-low 3.3 yards per rush and ranking third in passing defense.

Meanwhile, New England is returning home after a 3-0 road trip, but their home record against the spread in 2025 is only 1-2. The Patriots struggle defensively, ranking 30th in red-zone defense and in the bottom 10 in passing defense. With Cleveland’s strong defense and ability to avoid turnovers with rookie quarterback Dillon Gabriel, the model projects the Browns to stay within a touchdown, prevailing against the spread in over 50% of simulations.

Another notable Week 8 NFL prediction from the model is that the Atlanta Falcons (-7.5, 44.5) will cover the spread against the Miami Dolphins in over 50% of simulations. Miami is coming off a disastrous 31-6 loss to Cleveland, plagued by turnovers and defensive struggles. Tua Tagovailoa has thrown three interceptions in back-to-back games, a feat not seen since Philip Rivers in 2019.

Miami’s overall performance has been underwhelming, ranking in the bottom eight in points scored, yards gained, scoring defense, and total defense. They also have a poor turnover differential (-6). The Falcons, on the other hand, will be playing at home, where Michael Penix Jr. has a significantly better passer rating (95.2) compared to his road rating (67.8). The model projects Penix to have three more touchdown passes than interceptions, while Tagovailoa is expected to have an equal TD:INT ratio. As a result, the model projects the Falcons to cover the spread and the Over to hit in over 60% of simulations.

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The model has also made calls on who wins and covers in every other game on the Week 8 NFL schedule and just revealed five teams that win by nearly 70% of simulations, or more, potentially giving you a huge payday.

How to make Week 8 NFL picks:

The model has also made the call on who wins and covers in every other game on the Week 8 NFL schedule and just revealed five teams that win by nearly 70% of simulations, or more, potentially giving you a huge payday. You can only get every pick for every game at SportsLine.

So what Week 8 NFL picks can you make with confidence, and which five teams should you lock in now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $7,000, and find out.

Week 8 NFL betting odds, lines, live spreads, scores

Here is a look at the Week 8 NFL betting odds, lines and spreads:

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